Effect of vascular endothelial growth factor (VEGF) on tympanic perforations in Long-Evans rats
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Keywords
Angiogenesis, tympanic perforations, VEGF
Abstract
Background: Angiogenesis is the development of new blood vessels from a pre-existing vascular network. It involves a sequence of complex events, and it is essential for reparative processes. There are multiple angiogenesis stimulating factors, among which are several growth factors, such as vascular endothelial growth factor (VEGF). Because of their role in reparative processes, proangiogenic factors have been used to repair tympanic perforations. Aim: To assess the effect of VEGF on tympanic perforations of Long-Evans rats. Methods: Fifteen (15) adult rats were used in this study. Tympanic perforations, carried out bilaterally, were randomly instilled with either saline or VEGF, and the tympanic membranes were visualized under a dissecting microscope at 9, 15 and 21 days postperforation. Animals were sacrificed on day 21, and the tympanic width was histologically studied. Results: There was no inductive effect of VEGF on the healing of tympanic perforations. There was an increase in tympanic membrane width in rats treated with VEGF.
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